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Boston Children's Hospital to Tap IBM Watson to Tackle Rare Pediatric Diseases 2015.11.15

Boston, USA - November 10, 2015 - IBM (NYSE: IBM) and Boston Children's Hospital today announced that they intend to collaborate to apply IBM's Watson cognitive platform to help clinicians identify possible options for the diagnosis and treatment of rare pediatric diseases. The news was unveiled at the Global Pediatric Innovation Summit + Awards (#PedInno15). In an initial project focused on kidney disease, Watson will analyze the massive volumes of scientific literature and clinical databases on the Watson Health Cloud to match genetic mutations to diseases and help uncover insights that could help clinicians identify treatment options. At Boston Children's, investigators at The Manton Center for Orphan Disease Research are focused on diagnosing children with a wide variety of rare genetic conditions.

Dr. Christopher Walsh, Chief of Genetics at Boston Children's Hospital explores the IBM Watson for Genomics Dashboard.
IBM and Boston Children's Hospital announced a new collaboration that aims to help clinicians identify potential diagnosis and treatment options for children with rare diseases using genomic data and cognitive technology.
Photo courtesy of IBM / Boston Children's Hospital
 

Boston, USA - November 10, 2015

• Collaboration Aims to Help Clinicians Identify Possible Diagnosis and Treatment Options Using Genomic Data and Cognitive Technology, Starting with Kidney Disease

IBM (NYSE: IBM) and Boston Children’s Hospital today announced that they intend to collaborate to apply IBM’s Watson cognitive platform to help clinicians identify possible options for the diagnosis and treatment of rare pediatric diseases.

The news was unveiled at the Global Pediatric Innovation Summit + Awards (#PedInno15).

Photo courtesy of IBM
 
In an initial project focused on kidney disease, Watson will analyze the massive volumes of scientific literature and clinical databases on the Watson Health Cloud to match genetic mutations to diseases and help uncover insights that could help clinicians identify treatment options.

Today about 1 in 10 Americans suffer from a rare disease, and half of these patients are children, according to the Global Genes Project. There are some 7,000 known rare disorders ranging from benign abnormalities to life-threatening disease.

Deborah DiSanzo, general manager, IBM Watson Health.
Photo courtesy of IBM
 
Many affected children pass away before a diagnosis can be made, leaving families to grieve without knowing what might have been done to help them, or how to avoid additional brothers or sisters being affected.

At Boston Children’s, investigators at The Manton Center for Orphan Disease Research are focused on diagnosing children with a wide variety of rare genetic conditions.

The Technology & Innovation Development Office (TIDO) is the industry gateway to Boston Children's Hospital researchers, and biomedical innovations and technologies in all major biomedical markets for both pediatric and adult applications.
Photo courtesy of Boston Children's Hospital
 
While strides have been made, the interpretation of sequencing results can be a labor-intensive process, presenting an overload of information whose analysis may not always yield a definitive causative variant.

In the new collaboration, Watson will be trained in nephrology by reading related medical literature and aggregating information on causative mutations for steroid-resistant nephrotic syndrome (SRNS), a rare genetic form of kidney disease.

Innovation is at the core of Boston Children’s Hospital.
Since its inception in the summer of 2010, Boston Children’s Innovation Acceleration Program (IAP) has been a mentor and guide for the hospital’s best and brightest innovators.
Formed upon the recommendations of the Task Force for Clinical Innovation (a 14-member cross section of hospital leadership) and with the support of executive leadership, the IAP has defined the path for innovation at all levels of the institution.
Photo courtesy of Boston Children's Hospital
 
Then, experts at Boston Children’s Hospital intend to feed genomic sequencing data from retrospective patients into Watson to further train the system.

The goal is to create a cognitive system that can help clinicians interpret a child’s genome sequencing data, compare this with medical literature and quickly identify anomalies that may be responsible for the unexplained symptoms.

Christopher Walsh, MD, PhD, director of the Division of Genetics and Genomics at Boston Children’s Hospital.
Photo courtesy of Boston Children's Hospital
 
“Coping with an undiagnosed illness is a tremendous challenge for many of the children and families we see,”
said Christopher Walsh, MD, PhD, director of the Division of Genetics and Genomics at Boston Children’s Hospital.
“Watson can help us ensure we’ve left no stone unturned in our search to diagnose and cure these rare diseases so we can uncover all relevant insights from the patient’s clinical history, DNA data, supporting evidence and population health data.”

Christopher Walsh, MD, PhD, director of the Division of Genetics and Genomics at Boston Children’s Hospital works with the Watson for Genomics system.
Photo courtesy of IBM / Boston Children's Hospital
 
Even with a diagnosis, effective treatment for rare conditions can be elusive.

For example, SRNS are usually unresponsive to immunosuppressive therapy, and often must go on chronic dialysis or wait for a kidney transplant - only to have their disease frequently recur in the new organ.

Deborah DiSanzo, general manager, IBM Watson Health.
Photo courtesy of IBM
 
“One of Watson’s talents is quickly finding hidden insights and connecting patterns in massive volumes of data,”
said Deborah DiSanzo, general manager, IBM Watson Health.
“Rare disease diagnosis is a fitting application for cognitive technology that can assimilate different types and sources of data to help doctors solve medical mysteries. For the kids and their families suffering without a diagnosis, our goal is to team with the world’s leading experts to create a cognitive tool that will make it easier for doctors to find the needle in the haystack, uncovering all relevant medical advances to support effective care for the child.”

Friedhelm Hildebrandt, MD, chief of the Division of Nephrology at Boston Children’s and Claritas Genomics.
As Hildebrandt shows here, the ADCK4 protein localizes in the mitochondria (left image) and, when absent, causes zebrafish to show symptoms mirroring the human disease (shown at right).
Photo courtesy of Boston Children's Hospital
 
The kidney project will be done in collaboration with Friedhelm Hildebrandt, MD, chief of the Division of Nephrology at Boston Children’s and Claritas Genomics.

Following its successful completion, Boston Children’s plans to expand the effort into undiagnosed neurologic disorders and other disease areas studied by The Manton Center, improving diagnostic and treatment services for patients nationwide.

Boston Children’s Hospital is part of the Undiagnosed Diseases Network, a NIH program that aims to solve medical mysteries by integrating genetics, genomics, and rare disease expertise.

Boston Children’s was also the incubator behind Claritas Genomics, a genetic diagnostic laboratory that offers genetic testing and develops new diagnostic tests and solutions, and organizer of the CLARITY Undiagnosed Challenge, a crowd sourcing competition seeking best practices in clinical genomics.

The results and winner of the Challenge will be announced at the Boston Children’s Hospital Global Pediatric Innovation Summit on November 10.

Boston Children’s Hospital announced today at the Global Pediatric Innovation Summit + Awards the results of its international CLARITY Undiagnosed Challenge.
In this genomics competition, 26 registered teams from seven countries sought to interpret DNA sequences and provide information to five families about conditions that had eluded diagnosis despite multiple doctor visits, tests and genetic studies.
Representatives from the winning team, Nationwide Children's Hospital (Columbus, OH), was awarded USD 25,000 - receive their prize.
Pictured from left to right: Catherine Brownstein, Donald Corsmeier, Peter White, Alan Beggs.
Photo courtesy of Boston Children's Hospital
 
IBM has been developing Watson’s ability to analyze genomic data in collaboration with leading cancer centers around the world.

The system is currently being used at 16 cancer institutes to analyze and translate genomic data to help oncologists uncover personalized treatment options.

The new project with Boston Children’s represents the first time this technology will be applied to help clinicians efficiently identify possible options for rare disease diagnosis and treatment.

The Manton Center for Orphan Disease Research at Boston Children's Hospital (BCH) was created to develop new methods for understanding, diagnosing and treating unusual diseases and to apply this knowledge to make fundamental scientific advances with broad implications for human health.
Jorg Richter visits the Manton Center after biking coast to coast across the United States for rare disease awareness.
Photo courtesy of Boston Children's Hospital
 
IBM and Boston Children’s are also working together to build OPENPediatrics, an online platform designed to bring life-saving medical knowledge to pediatric caregivers worldwide.

In September, the two organizations announced they will integrate Watson’s deep and iterative question and answer capability to enhance and scale the OPENPediatrics initiative.

Learn more about this story at
http://www.ibm.com/blogs/think/2015/11/10/cognitive-technologies-are-critical-to-improving-healthcare/  


About Boston Children’s Hospital

Boston Children’s Hospital is home to the world’s largest research enterprise based at a pediatric medical center, where its discoveries have benefited both children and adults since 1869.

More than 1,100 scientists, including seven members of the National Academy of Sciences, 11 members of the Institute of Medicine and 10 members of the Howard Hughes Medical Institute comprise Boston Children’s research community.

Founded as a 20-bed hospital for children, Boston Children’s today is a 397-bed comprehensive center for pediatric and adolescent health care.

Boston Children’s is also the pediatric teaching affiliate of Harvard Medical School.

For more, visit our Vector and Thriving blogs and follow us on our social media channels:
@BostonChildrens,
@BCH_Innovations,
Facebook and YouTube.


About IBM Watson Health

Watson is the first commercially available cognitive computing capability representing a new era in computing.

The system, delivered through the cloud, analyzes high volumes of data, understands complex questions posed in natural language, and proposes evidence-based answers.

Watson continuously learns, gaining in value and knowledge over time, from previous interactions.

In April 2015, the company launched IBM Watson Health and the Watson Health Cloud platform.

The new unit will help improve the ability of doctors, researchers and insurers to innovate by surfacing insights from the massive amount of personal health data being created and shared daily.

The Watson Health Cloud allows this information to be de-identified, shared and combined with a dynamic and constantly growing aggregated view of clinical, research and social health data.

For more information on IBM Watson,
visit: ibm.com/watson.

For more information on IBM Watson Health,
visit: ibm.com/watsonhealth

Check out the IBM Watson press kit at:
http://www-03.ibm.com/press/us/en/presskit/27297.wss  

Join the conversation at #ibmwatson and #watsonhealth.

Follow Watson on Facebook and see Watson on YouTube and Flickr.


Contacts information

Christine Douglass
IBM Media Relations
1 (415) 535-4479
cgdouglass@us.ibm.com  

Kristen Dattoli
Boston Children’s Hospital Media Relations
1 (617) 919-3141
kristen.dattoli@childrens.harvard.edu  


Source: IBM

http://www-03.ibm.com/  



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